Disorders affecting vitamin B 6 metabolism
نویسندگان
چکیده
منابع مشابه
Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism.
BACKGROUND A low circulating vitamin B-6 concentration, which is an independent risk factor for cardiovascular disease, is commonly seen in human inflammation. OBJECTIVE We investigated whether cyclooxygenase inhibitors alter vitamin B-6 metabolism. DESIGN To investigate whether subjects taking a cyclooxygenase inhibitor had an altered vitamin B-6 profile, we conducted a cross-sectional stu...
متن کاملVitamin B-6 Metabolism and Interactions with TNAP.
Two observations stimulated the interest in vitamin B-6 and alkaline phosphatase in brain: the marked increase in plasma pyridoxal phosphate and the occurrence of pyridoxine responsive seizures in hypophosphatasia. The increase in plasma pyridoxal phosphate indicates the importance of tissue non-specific alkaline phosphatase (TNAP) in transferring vitamin B-6 into the tissues. Vitamin B-6 is in...
متن کاملInborn errors affecting vitamin B6 metabolism
Vitamin B 6 is an important vitamin for normal brain function. The metabolism of dietary vitamin B 6 to its active cofactor pyridoxal 5´-phosphate is described. The mechanism of action of pyridoxal 5´-phosphate is described, as are some important functions in the brain. The clinical features and biochemistry of three inborn errors of metabolism affecting brain pyridoxal 5´-phosphate concentrati...
متن کاملFactors Affecting the Absorption of Vitamin B,,
1. The absorption of radioactive cobalamin was measured by a whole-body counting technique in control subjects and in patients with pernicious anaemia. 2. The absorption of cyanocobalamin by patients with pernicious anaemia was decreased by charcoal but not by bile or saliva. 3. The absorption of cyanocobalamin by control subjects was not affected by food but was significantly increased by pent...
متن کاملThe effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Homocysteine, an atherogenic amino acid, is either remethylated to methionine or metabolized to cysteine by the transsulfuration pathway. The biochemical conversion of homocysteine to cysteine is dependent upon two consecutive, vitamin B-6-dependent reactions. To study the effect of a selective vitamin B-6 deficiency on transsulfuration, we performed oral methionine load tests on 22 vitamin B-6...
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ژورنال
عنوان ژورنال: Journal of Inherited Metabolic Disease
سال: 2019
ISSN: 0141-8955,1573-2665
DOI: 10.1002/jimd.12060